


These properties of melatonin have led to an interest in utilizing this hormone for the treatment of IBD. The hormone melatonin, which regulates the sleep-wake cycle, is also produced in the intestines, where it can modulate immune response. A new study in a mouse model of IBD now shows that melatonin caused changes in the gut microbiota composition, resulting in increased disease severity and delayed recovery from IBD.Īlthough biologics and immunosuppressive drugs can be effective against inflammatory bowel disease (IBD), some individuals do not respond to these treatments and require surgery.Melatonin is also produced in the intestine, where it can modulate the gut immune system, suggesting this hormone may have potential as a therapeutic for IBD.Melatonin is a hormone synthesized in the brain that regulates the circadian rhythm and is used as a supplement to promote sleep.Inflammatory bowel disease (IBD) is associated with changes in gut microbiota composition and intestinal inflammation.Share on Pinterest Researchers say melatonin can be helpful for improving sleep but may increase gut inflammation in some people.
